PeriHarmon

1. Black Cohosh Root Extract

Chemical Form: Standardized Triterpene Glycosides

• Mechanism: A non-hormonal botanical studied for its potential effects on neurotransmitter pathways involved in thermoregulation and temperature regulation.

• Clinical Benefit: May help manage menopausal symptoms such as hot flashes and night sweats, although clinical evidence for its effectiveness is mixed.

• Formulation Role: Included to support vasomotor comfort during perimenopause and menopause.

2. Red Clover Extract

Chemical Form: Standardized to 8% Isoflavones

• Mechanism: Contains isoflavones, including genistein, daidzein, biochanin A, and formononetin, which can interact with estrogen receptors, including estrogen receptor beta (ER-β).

• Clinical Benefit: Has been studied for its potential role in managing menopausal symptoms, although evidence of benefit remains inconsistent.

• Formulation Role: Provides plant-derived isoflavones as part of a formulation intended to support women's health during the menopausal transition.

3. KSM-66 Ashwagandha Root Extract

Chemical Form: Full-Spectrum Root Extract (More Than 5% Withanolides)

• Mechanism: An adaptogenic botanical studied for its potential effects on stress response and physiological markers associated with stress.

• Clinical Benefit: May support stress management, relaxation, and sleep quality, although results can vary between individuals.

• Formulation Role: Included to support emotional well-being and stress management during periods of hormonal transition.

4. Saffron Extract

Chemical Form: Standardized Crocin & Safranal Neuro-Botanical Extract

• Mechanism: Contains bioactive compounds, including crocin and safranal, that have been studied for their potential effects on neurotransmitter signaling and mood regulation.

• Clinical Benefit: May support mood and emotional well-being, with some research exploring its potential effects on anxiety and sleep quality.

• Formulation Role: Included to support mood balance and relaxation as part of a comprehensive menopause-support formulation.

5. Vitamin D3 & Vitamin K2 (MK-7)

Chemical Form: Synergistic Bone Matrix Dual-Vitamin Complex

• Mechanism: Vitamin D3 supports intestinal calcium absorption, while vitamin K2 (menaquinone-7) contributes to the activation of vitamin K-dependent proteins, including osteocalcin, involved in bone metabolism.

• Clinical Benefit: Both vitamins contribute to maintaining normal bone health. Vitamin D also supports normal calcium levels and muscle function.

• Formulation Role: Provides complementary nutritional support for bone health and calcium metabolism during perimenopause and menopause.